TGF-b/Smad signaling through DOCK4 facilitates lung adenocarcinoma metastasis
نویسندگان
چکیده
Jia-Ray Yu, Yilin Tai, Ying Jin, Molly C. Hammell, J. Erby Wilkinson, Jae-Seok Roe, Christopher R. Vakoc, and Linda Van Aelst Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA; Graduate Program in Genetics, Stony Brook University, Stony Brook, New York 11794, USA; Unit for Laboratory Animal Medicine, Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA
منابع مشابه
TGF-β/Smad signaling through DOCK4 facilitates lung adenocarcinoma metastasis.
The mechanisms by which TGF-β promotes lung adenocarcinoma (ADC) metastasis are largely unknown. Here, we report that in lung ADC cells, TGF-β potently induces expression of DOCK4, but not other DOCK family members, via the Smad pathway and that DOCK4 induction mediates TGF-β's prometastatic effects by enhancing tumor cell extravasation. TGF-β-induced DOCK4 stimulates lung ADC cell protrusion, ...
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